Dr. Phillips is Principal Investigator on the following grants:
- BABES - Caregiving Effects on the Early Development of Infant Brain-Behavior Relationships
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Along with Alison Hipwell, PhD, Dr. Phillips aims to examine prospective relationships among neural circuitry structure and intrinsic functional connectivity at 3 and 9 months, and change between 3 to 9 months, and 3-18 month changes in emotional reactivity and regulation.
- BBRF - Mitochondrial Dysfunction, Reward And Dopamine In Bipolar Disorder: A Novel Approach Using Mitochondrial Complex I Imaging
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Dr. Phillips will examine mitochondrial Complex I (MC-I) in the brain in individuals with bipolar disorder (BD), and determine relationships among MC-I and indices of neural activity and neurotransmission known to be aberrant in BD. The study will guide future, larger-scale studies examining MC-I in BD to aid BD risk detection and the development of new, mitochondrial dysfunction-informed treatments.
- CENTRIM-BD - Elucidating Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder
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Dr. Phillips seeks to find out how a ketogenic diet influences brain structure and function in adults with Bipolar Disorder.
- DIAMOND 3 - Reward, Impulsive Sensation Seeking and Emotion Dysregulation: Neural Mechanisms Underlying Risk for Bipolar Disorder in Young Adults
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This is a NIMH-funded renewal of our original Diamond study in which we aim to better identify bipolar spectrum disorders (BPSD) in at-risk young adults, and provide neural targets for novel (e.g., neuromodulation) interventions to delay or prevent, BPSD.
- ENCORE - Project 3: Linking Persistent Avoidance with Abnormalities in the OCD Neural Network
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The goal of Project 3 is to characterize, in OCD, white matter (WM) bundle and functional neural abnormalities among regions in a putative OCD neural network that are associated with persistent avoidance, a characteristic feature of OCD, using the Center framework to closely collaborate with basic neuroscience and clinical intervention projects, and cores.
- ENCORE 2 - Linking OCD-like Behaviors with Abnormalities in the OCD Neural Network
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Dr. Phillips along with Co-Invesitigators Amelia Versace, MD, Henry Chase, PhD and Robert Hodak, MD seeks to to characterize, in OCD, white matter (WM) bundle and functional neural abnormalities among regions in a putative OCD neural network that are associated with persistent avoidance, a characteristic feature of OCD, using the Center framework to closely collaborate with basic neuroscience and clinical intervention projects, and cores.
- MULTIMODAL - Linking mania/hypomania with abnormal reward expectancy- and approach-related neural network activity and dopamine release
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Dr. Phillips along with Dr. Rajesh Narendran and Dr. Deepak Sarpal this study seeks to elucidate the neurobiological mechanisms underlying two key characteristics that predispose to, and are associated with, mania/hypomania: elevated reward sensitivity/ goal overvaluation; and higher than normal levels of often risky, approach-oriented decisions and behaviors resulting from heightened reward valuation, which can be examined in uncertain reward expectancy (RE) and approach-avoidance decision-making contexts.
- PEAR - Moving beyond the pain-suicidality link: An Investigation of Fluctuations in Social Threat and Neural Response to Social Threat in Momentary Pain and Proximal Risk for Suicidal Ideation in adolescence
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Dr. Phillips’ and Dr. Caroline Oppenheimer’s findings will advance understanding beyond the pain–suicidality link by pinpointing (a) proximal factors predicting when suicidal ideation (SI) occurs (i.e., in moments of social threat or physical pain), (b) neural vulnerability markers identifying who develops SI, and (c) how SI may develop through interactions between negative social environments and altered function in the pain system. Findings will inform novel targets for just in-time interventions that deliver skills through electronic devices in critical moments of risk.
- tFUS - Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorder
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This is a proof-of-concept study and a promising way forward to develop new device-based interventions for individuals with Cocaine Use Disorder.
- TREAT-BD - Elucidating Neural Mechanisms of Hypo/mania Using Theta Burst Stimulation
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As part of this study, we attempt to determine the impact of TBS on the vlPFC and related brain circuitry activity and functional connectivity during reward anticipation.
Dr. Phillips is Co-Investigator on the following studies:
- Development of Anhedonia in High-Risk Adolescents
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Development of Anhedonia in High-Risk Adolescents
Erika Forbes, PhD, is PI on this study that seeks to examine developmental changes in subjective, neural, and behavioral aspects of anhedonia in adolescents, who are either typically developing or have a first-degree relative with a history of depression, bipolar disorder, or schizophrenia-spectrum.
- Emotion Regulation Circuitries in Youth with Mild Traumatic Brain Injury
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Emotion Regulation Circuitries in Youth with Mild Traumatic Brain Injury
Amelia Versace, MD, and Anthony Kontos, PhD, are MPIs on this study which uses multimodal neuroimaging techniques to characterize the brain structure and functioning of emotional regulation circuitries in 200 youth 1 week after injury.
- Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
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Transdiagnostic Neural Mechanisms Underlying Dimensions of Negative Affectivity in Depression and Anxiety
Jay Fournier, PhD tests a novel model of neural dysfunction during emotion regulation associated with excessive self-consciousness and to examine the real-world consequences of that dysfunction.
- The Contribution of Aberrant Anticipatory Processing to Spectrum Depression and Mania, and Cognitive and Emotional Dysfunction in Major Depressive and Bipolar Disorders
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The Contribution of Aberrant Anticipatory Processing to Spectrum Depression and Mania, and Cognitive and Emotional Dysfunction in Major Depressive and Bipolar Disorders
Anna Manelis, PhD proposes that aberrant anticipatory processing preceding performance on episodic and working memory tasks may be an important factor that mediates the relationship between mood symptoms and functioning in individuals with MDD and BD.
- Theta Burst Stimulation of Frontostriatal Reward Circuitry in Young Adults with Depression
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Theta Burst Stimulation of Frontostriatal Reward Circuitry in Young Adults with Depression
Erika Forbes, PhD, leads this study, which seeks to manipulate positive valence systems at the neural level to understand their function, and potentially reveal a source of heterogeneity relevant to future research in experimental.
- Using fMRI of Autobiographical Memory Recall to Determine Risk and Resilience Endophenotypes in Familial Major Depressive
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Using fMRI of Autobiographical Memory Recall to Determine Risk and Resilience Endophenotypes in Familial Major Depressive
Kymberly Young, PhD seeks to examine whether this correctable mechanism also convers vulnerability or resilience to developing MDD in a longitudinal design following young adults at high risk for developing MDD.
- From Manic Symptoms to Bipolar Disorder: Neural-behavioral Markers Using Two Analytic Models
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From Manic Symptoms to Bipolar Disorder: Neural-behavioral Markers Using Two Analytic Models
Michele Bertocci, PhD, and Rasim Diler, MD, investigate brain-behavior relations in the most severely ill youth during inpatient stays and aim to build a predictive model of bipolar disorder.